7/6/2023 0 Comments Acetaminophen antidote![]() Acetylcysteine after Acetaminophen Overdose in Mice. Other medications, such as liver protectants and Vitamin C, may also be given. Longer half-lives reflect a greater toxic effect on the liver.Ĭlinical Pharmacology & Therapeutics (2002) 71, 221–225 doi: 10.1067/mcp.2002. Acute Ethanol Administration Reduces the Antidote Effect of N-. An antidote is available for acetaminophen toxicity called N-acetylcysteine. ConclusionsĪcetaminophen half-life correlates well with the degree of liver damage in patients treated with the antidote N-acetylcysteine. Thirty-three of 41 patients (81%) with an acetaminophen half-life 5.5 hours (positive predictive value, 91%) and in 15 of 58 patients with a half-life below this limit (negative predictive value, 74%) despite treatment with N-acetylcysteine. Forty-eight patients with no or little hepatotoxicity (ALT 4 hours was observed in 71 patients, and 56 of those (79%) had hepatotoxicity(ALT >1000 U/L or coma). ![]() Overall, the median acetaminophen half-life was 5.4 hours (range, 0.8-119.7 hours). ![]() A minimum of 2 plasma acetaminophen values >20 μmol/L were available for calculation of acetaminophen half-life, assuming first-order kinetics. Prospectively, 112 patients with acetaminophen overdosage all treated with intravenous N-acetylcysteine were studied. N-acetyl cysteine (NAC) is an effective antidote for acetaminophen. Acetaminophen half-life has not been studied in patients receiving the antidote N-acetylcysteine. Acetaminophen is a non-steroidal anti-inflammatory drug (NSAID) with a mechanism of action different from other NSAIDs. Liver toxicity may result from an acute overdose as well as from chronic excessive ingestion. ![]() A plasma acetaminophen (INN, paracetamol) half-life of more than 4 hours has been correlated with hepatotoxicity in acetaminophen overdosing not treated with an antidote.
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